Phase I and pharmacological study of sequential intravenous topotecan and oral etoposide
نویسندگان
چکیده
منابع مشابه
A phase I and translational study of sequential administration of the topoisomerase I and II inhibitors topotecan and etoposide.
Because topoisomerase (topo) I- and topo II-targeting agents exert their principal effects on the two major classes of enzymes involved in regulating DNA topology in the cell, there has been considerable interest in evaluating combinations of these classes of agents. In preclinical studies of inhibitors of topo I and topo II in combination, drug scheduling and sequencing have been critical dete...
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چکیده ندارد.
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1997
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1997.585